Chemicals are part of our daily lives, and we are exposed to multiple chemicals through multiple pathways. Significant questions and huge gaps remain about their adverse human health impacts and societal costs. Relevant scientific evidence contributing to regulation of hazardous chemicals requires a holistic approach to assess simultaneous exposure to multiple compounds.
We use the last advances in analytical chemistry (advanced HRMS-based approaches) to obtain a more comprehensive understanding of the universe of chemicals that accumulate (or pseudo-accumulate) in humans and their link with the environment. Also, we link the exposure to those compounds with adverse health effects by (I) investigating changes in the metabolic pathways (applying metabolomics) and (II) evaluating adverse health outcomes in collaboration with epidemiologists. We also focus our research on the development of early warning systems for the detection of chemicals that may pose a threat to human health to prevent possible threats.