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DTSTART;TZID=Europe/Madrid:20200925T160000
DTEND;TZID=Europe/Madrid:20200925T190000
DTSTAMP:20261018T161739Z
CREATED:20200914T141143Z
LAST-MODIFIED:20261018T161739Z
UID:13714-1601049600-1601060400@idaea.csic.es
SUMMARY:PhD thesis defence by Rubén Francisco Martínez López
DESCRIPTION:The PhD researcher Rubén Francisco Martínez López from the Environmental Toxicology group\, will defend his thesis next 25th September 2020 at 16:00h. \nThesis will be live streamed on this link: https://meet.lync.com/ubarcelona-ub/ncarbo/TM2H4VI6 \nTitle: Integrative analysis of endocrine disruption in zebrafish (Danio rerio) \nDirector: Dr. Benjamin Cayetano Piña Capó and Laia Navarro Martín \nAbstract: \nUnderstanding the mode of action of different pollutants and xenobiotics in human and wildlife is a key step in environmental risk assessment. Omic technologies allow the study of the global status at different biological levels (transcriptome\, metabolome\, lipidome…) from a holistic and integrative point of view. The omic data fusion and integration of the effects at these different levels is an extremely useful method to elucidate the mode of action (MoA) of the pollutants and to propose adverse outcome pathways (AOPs). \nIn this way\, the aim of this thesis is to determine molecular and phenotypical signatures of exposure of several endocrine disrupting chemicals (EDCs) on zebrafish (Danio rerio) eleutheroembryos\, which constitutes an excellent model for endocrine disruption. \nMorphometric and transcriptomic (RNA-Sequencing) studies were carried out in individuals exposed to bisphenol A (BPA)\, perfluorooctanesulfonate (PFOS) and tributyltin (TBT). Further metabolic\, epigenetic (DNA methylation and miRNAs) and lipidomic (thin layer chromatography and high performance liquid chromatography – mass spectrometry) studies were performed only in BPA-exposed individuals. Main effects of BPA included lipid metabolism disruption\, yolk sac malabsorption syndrome and lipid retention (obesogenicity)\, visual system alteration\, and estrogenicity. Some of its effects were long-term persistent and could be mediated by epigenetic mechanisms. PFOS had immunosuppressive and anorexic-like properties\, it disrupted the transcription of genes related to cell adhesion molecules (CAMs)\, and the exposed eleutheroembryos presented muscle-skeletal alterations (scoliosis and kyphosis). Finally\, TBT disrupted the transcription of genes related to steroid and cell cycle metabolism\, and elicited a general developmental delay (diapause-arrest effect) in the exposed individuals. \nPhenotypic observations were related to their transcriptomic alterations and their proposed molecular initiation event (MIE)\, allowing the design of an AOP for each of the studied EDCs. Overall\, this thesis shows the usefulness of transcriptomics and of data integration at different biological levels to discern AOPs and MIE\, therefore contributing to a deeper comprehension of the toxicity and the mode of action of BPA\, PFOS and TBT. We consider that these results can be extrapolated to understand the toxic effects of these compounds in other animals\, including humans.
URL:https://idaea.csic.es/event/phd-thesis-defence-by-ruben-francisco-martinez-lopez/
LOCATION:Sala de Graus (edifici Aulari)\, Facultat de Biologia UB
CATEGORIES:Thesis Defence
ATTACH;FMTTYPE=image/jpeg:https://idaea.csic.es/wp-content/uploads/2026/10/RubenFranciscoMartinez.jpg
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DTSTART;TZID=Europe/Madrid:20200921T120000
DTEND;TZID=Europe/Madrid:20200921T150000
DTSTAMP:20261018T161739Z
CREATED:20200910T141413Z
LAST-MODIFIED:20261018T161739Z
UID:13713-1600689600-1600700400@idaea.csic.es
SUMMARY:PhD thesis defence by Anna Marqueño Bassols
DESCRIPTION:The PhD researcher Anna Marqueño Bassols from the Environmental Toxicology group\, will defend her thesis next 21st September 2020 at 12:00h. \nTitle: New tools for the detection of lipid disruptors and environmental obesogens \nDirector: Dr. Cinta Porte Visa \nAbstract: \nLipidomics is one of the newest omics sciences\, which has proven their utility in medical research for the discovery of biomarkers and altered metabolic pathways related to disease. Its application in environmental sciences is becoming relevant due to the important role of lipids in development\, maintenance\, and reproduction of metazoans. At the cellular level\, lipids are involved in energy storage\, signaling\, and exhibit structural functions. Organisms contain thousands of different lipid species with rather similar structures. The latest advances in mass spectrometry have prompted the field of lipidomics\, allowing a better annotation of the lipid species of different biological matrices (cells\, biofluids\, tissues)\, but also the detection of alterations as a response to chemical pollution exposure. \nThree analytical techniques based on high-resolution mass spectrometry have been used for the characterization of the lipid profile of different biological models. The first method\, flow injection analysis coupled to high-resolution mass spectrometry represents a powerful tool since\, just in two minutes\, it provides a quick screening of the lipid profile of cellular lipids. The other two methods\, which incorporate ultra-high performance liquid chromatography for the previous separation of the lipids\, have allowed the detection of minority species\, and the application of tandem mass spectrometry together with an untargeted approach for data processing provided a more comprehensive lipid profile\, together with the confirmation of lipid identities. \nThese analytical techniques have been used for the study of the impact of several widespread environmental pollutants on the lipid metabolism of both human and fish cell models\, comprising plastic additives (BPA\, BPF\, BADGE\, BADGE·H2O\, BADGE·2HCl)\, the obesogenic compound tributyltin\, all-trans retinoic acid\, the synthetic progestin drospirenone and a complex mixture of environmental pollutants (field study). Lipidomics\, together with some toxicological assays and the use of real-time polymerase chain reaction have allowed drawing a more complete scenario of the toxicological effects of the chemicals under study. Overall\, this thesis aims to contribute to the use of lipidomics in environmental research by proposing useful biological models and workflows for the characterization of the mode of action of environmental pollutants with the capability to act as lipid disruptors.
URL:https://idaea.csic.es/event/phd-thesis-defence-by-anna-marqueno-bassols/
LOCATION:Aula Eduard Fontserè\, Facultat de Física i Química (UB)
CATEGORIES:Thesis Defence
ATTACH;FMTTYPE=image/png:https://idaea.csic.es/wp-content/uploads/2026/10/AnnaMarqueno.png
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