PhD Thesis Defence by Maryam Pyambri

The predoctoral researcher Maryam Pyambri will defend her thesis on 6th November at 10:00h in Sala de Graus Eduard Fontserè, Facultat de Química, Universitat de Barcelona

Title: Integrating New Approach Methodologies for the Toxicological Assessment of Indoor Air Pollutants.

Directors: Carmen Bedia and Joaquim Jaumot.

Thesis Committee: Àngels Sierra, Francesc Puig and Pablo Gago

Abstract:
This PhD explores the toxicological effects of indoor air pollutants, with a focus on organophosphate flame retardants (OPFRs) present in indoor dust. By combining advanced in vitro models, lipidomics, and chemometric analysis, the research investigates how indoor exposures affect lung and neural systems. The findings reveal that indoor dust and OPFRs can trigger oxidative stress, inflammation, and significant disruptions in lipid metabolism. The work highlights lipid dysregulation as a key mechanism of toxicity and supports the use of human-relevant New Approach Methodologies (NAMs) in environmental health research.